]> C21.0 Anus, NOS (excluding skin of anus and perianal skin C44.5) C21.1 Anal canal C21.2 Cloacogenic zone C21.8 Overlapping lesion of rectum, anus and anal canal Note: Skin of anus is coded separately (C44.5). &commontumorsizeanus; CS Extension Note 1: High-grade squamous intraepithelial lesions (HSIL) and anal intraepithelial neoplasia (AIN) grade II III are not normally collected by cancer registries. AIN II III or AIN III is reportable to standard-setters (except the Commission on Cancer). If your registry collects any of these, use code 000. Note 2: The assignment of T1, T2 , and T3 categories for tumors of the anus is based on tumor size. A physician's statement of the T category may be used to code CS Tumor Size and/or CS Extension if this is the only information in the medical record regarding one or both of these fields. However the two fields are coded independently: for example the record may document size but not extension, other than the physician's statement of the T category. Use code 310, 320, 330, or 850 as appropriate to code CS Extension based on a statement of T when no other extension information is available. Note 3: Code incidental finding of malignancy in hemorrhoid according to greatest extension of tumor into wall of anus. Code as Localized, NOS if extension not specified. Note 4: Codes 400-750 are used for contiguous extension from the site of origin. Discontinuous involvement is coded in CS Mets at DX. Code Description TNM 7th Map TNM 6th Map SS77 Map SS2000 Map 000 Tis Tis IS IS 100 ^ * L L 110 Invades lamina propria ^ * L L 120 Invades muscularis mucosae ^ * L L 160 Invades submucosa (superficial invasion) ^ * L L 200 Invades muscularis propria (internal sphincter) ^ * L L 300 ^ * L L 310 Stated as T1 with no other information on extension ^ * L L 320 Stated as T2 with no other information on extension ^ * L L 330 Stated as T3 with no other information on extension ^ * L L 400 ^ * RE RE 600 T4 T4 RE RE 700 T4 T4 D D 750 T4 T4 D D 800 Further contiguous extension T4 T4 D D 850 Stated as T4 with no other information on extension T4 T4 RE RE 950 No evidence of primary tumor T0 T0 U U 999 TX TX U U ^ For CS Extension codes 100-400 ONLY, the T category for AJCC 7 staging is assigned based on the value of CS Tumor Size, as shown in the Extension Size Table for this schema. * For CS Extension codes 100-400 ONLY, the T category for AJCC 6 staging is assigned based on the value of CS Tumor Size, as shown in the Extension Size Table for this schema. &generalcstsexteval; CS Lymph Nodes Note 1: Code only regional nodes and nodes, NOS in this field. Distant nodes are coded in CS Mets at DX. Note 2: Use codes for anal canal unless tumor is stated to occur at the anus, arising just proximal to the squamous mucocutaneous junction or the anal verge. Note 3: For codes 400 and 405, the combination of unilateral internal iliac nodes and unilateral inguinal nodes must be on the same side. Use code 530 for bilateral combinations of internal iliac nodes and inguinal nodes. Note 4: Use codes for internal iliac nodes for combinations of perirectal and internal iliac nodes. Use codes 415, 425, and 440 for combinations of perirectal and superficial inguinal nodes. Code Description TNM 7 Map TNM 6 Map SS77 Map SS2000 Map 000 No regional lymph node involvement N0 N0 NONE NONE 100 N1 N1 RN RN 110 N1 N1 RN RN 120 N1 N1 RN RN 130 N1 N1 D RN 140 N1 N1 RN RN 200 N2 N2 RN RN 210 ERROR ERROR ERROR ERROR 300 N2 N2 D RN 310 N2 N2 RN RN 330 N2 N2 RN RN 350 Stated as N2 with no other information on regional lymph nodes N2 N2 RN RN 400 N2 N2 D RN 405 N2 N2 D RN 410 N3 N3 D RN 415 N3 N3 D RN 420 N3 N3 RN RN 425 N3 N3 D RN 440 N3 N3 D RN 470 N3 N3 D RN 490 N3 N3 D RN 500 N3 N3 RN RN 510 N3 N3 D RN 515 N3 N3 D RN 520 N3 N3 D RN 530 N3 N3 D D 550 N3 N3 RN RN 600 Regional lymph node(s), NOS N1 N1 RN RN 800 Lymph nodes, NOS N1 N1 RN RN 999 NX NX U U &generalregnodeseval; &generalreglnpos; &generalreglnexam; &generalmetsatdx; &generalmetseval; CS Site-Specific Factor 1 Human Papilloma Virus (HPV) Status Note 1: There is evidence that HPV plays a role in the pathogenesis of some cancers. HPV testing may be performed for prognostic purposes; testing may also be performed on metastatic sites to aid in determination of the primary site. Note 2: Record the results of any HPV testing performed on pathologic specimens from the primary tumor or a metastatic site, including lymph nodes. Do not record the results of blood tests or serology. Note 3: HPVs are divided into high-risk and low-risk types. The highest risk HPV types are types 16 and 18. Other high-risk types are 26, 31, 33, 35, 36, 45, 51, 52, 53, 56, 58, 59, 66, 67, 68, 69, 70, 73, 82, and 85. The HPV vaccine is designed to protect against types 16 and 18 (associated with cervical cancer) and types 6 and 11 (associated with genital warts). Low-risk types are 6, 11, 32, 34, 40, 42, 44, 54, 61, 62, 64, 71, 72, 74, 81, 83, 84, 87, and 89. Note 4: High-risk may be abbreviated hrHPV or HR-HPV. Note 5: Some tests for HPV, such as a hybrid capture test, may only report negative or positive results for high-risk HPV without identifying types. Use codes 000 or 060, respectively, to report those test results. Note 6: Codes 010-050 are hierarchical; use the highest code that applies. Code Description 000 010 HPV positive for low-risk types only 020 030 040 050 060 HPV positive for high-risk type(s), NOS, high-risk type(s) not stated 070 HPV positive, NOS, risk and type(s) not stated 888 988 997 Test ordered, results not in chart 998 999 ¬appssfactor2; ¬appssfactor3; ¬appssfactor4; ¬appssfactor5; ¬appssfactor6; ¬appnewssf7; ¬appnewssf8; ¬appnewssf9; ¬appnewssf10; ¬appnewssf11; ¬appnewssf12; ¬appnewssf13; ¬appnewssf14; ¬appnewssf15; ¬appnewssf16; ¬appnewssf17; ¬appnewssf18; ¬appnewssf19; ¬appnewssf20; ¬appnewssf21; ¬appnewssf22; ¬appnewssf23; ¬appnewssf24; ¬appnewssf25; &commonhistinclusioncarcinomanonnet; &commonhistologyexclusions1; AJCC TNM 7 Stage T N M Stage T0 N0 M0 ERROR T0 N1 M0 IIINOS T0 N2 M0 IIIB T0 N3 M0 IIIB T0 NX M0 UNK Tis N0 M0 0 Tis N1 M0 ERROR Tis N2 M0 ERROR Tis N3 M0 ERROR Tis NX M0 0 T1 N0 M0 I T1 N1 M0 IIIA T1 N2 M0 IIIB T1 N3 M0 IIIB T1 NX M0 UNK T2 N0 M0 II T2 N1 M0 IIIA T2 N2 M0 IIIB T2 N3 M0 IIIB T2 NX M0 UNK T3 N0 M0 II T3 N1 M0 IIIA T3 N2 M0 IIIB T3 N3 M0 IIIB T3 NX M0 UNK T4 N0 M0 IIIA T4 N1 M0 IIIB T4 N2 M0 IIIB T4 N3 M0 IIIB T4 NX M0 IIINOS TX N0 M0 UNK TX N1 M0 IIINOS TX N2 M0 IIIB TX N3 M0 IIIB TX NX M0 UNK T0 N0 M1 IV T0 N1 M1 IV T0 N2 M1 IV T0 N3 M1 IV T0 NX M1 IV Tis N0 M1 ERROR Tis N1 M1 ERROR Tis N2 M1 ERROR Tis N3 M1 ERROR Tis NX M1 ERROR T1 N0 M1 IV T1 N1 M1 IV T1 N2 M1 IV T1 N3 M1 IV T1 NX M1 IV T2 N0 M1 IV T2 N1 M1 IV T2 N2 M1 IV T2 N3 M1 IV T2 NX M1 IV T3 N0 M1 IV T3 N1 M1 IV T3 N2 M1 IV T3 N3 M1 IV T3 NX M1 IV T4 N0 M1 IV T4 N1 M1 IV T4 N2 M1 IV T4 N3 M1 IV T4 NX M1 IV TX N0 M1 IV TX N1 M1 IV TX N2 M1 IV TX N3 M1 IV TX NX M1 IV AJCC TNM 6 Stage T N M Stage T0 N0 M0 ERROR T0 N1 M0 IIIA T0 N2 M0 IIIB T0 N3 M0 IIIB T0 NX M0 UNK T0 N0 M1 IV T0 N1 M1 IV T0 N2 M1 IV T0 N3 M1 IV T0 NX M1 IV T0 N0 MX UNK T0 N1 MX UNK T0 N2 MX UNK T0 N3 MX UNK T0 NX MX UNK Tis N0 M0 0 Tis N1 M0 ERROR Tis N2 M0 ERROR Tis N3 M0 ERROR Tis NX M0 0 Tis N0 M1 ERROR Tis N1 M1 ERROR Tis N2 M1 ERROR Tis N3 M1 ERROR Tis NX M1 ERROR Tis N0 MX 0 Tis N1 MX ERROR Tis N2 MX ERROR Tis N3 MX ERROR Tis NX MX 0 T1 N0 M0 I T1 N1 M0 IIIA T1 N2 M0 IIIB T1 N3 M0 IIIB T1 NX M0 UNK T1 N0 M1 IV T1 N1 M1 IV T1 N2 M1 IV T1 N3 M1 IV T1 NX M1 IV T1 N0 MX UNK T1 N1 MX UNK T1 N2 MX UNK T1 N3 MX UNK T1 NX MX UNK T2 N0 M0 II T2 N1 M0 IIIA T2 N2 M0 IIIB T2 N3 M0 IIIB T2 NX M0 UNK T2 N0 M1 IV T2 N1 M1 IV T2 N2 M1 IV T2 N3 M1 IV T2 NX M1 IV T2 N0 MX UNK T2 N1 MX UNK T2 N2 MX UNK T2 N3 MX UNK T2 NX MX UNK T3 N0 M0 II T3 N1 M0 IIIA T3 N2 M0 IIIB T3 N3 M0 IIIB T3 NX M0 UNK T3 N0 M1 IV T3 N1 M1 IV T3 N2 M1 IV T3 N3 M1 IV T3 NX M1 IV T3 N0 MX UNK T3 N1 MX UNK T3 N2 MX UNK T3 N3 MX UNK T3 NX MX UNK T4 N0 M0 IIIA T4 N1 M0 IIIB T4 N2 M0 IIIB T4 N3 M0 IIIB T4 NX M0 UNK T4 N0 M1 IV T4 N1 M1 IV T4 N2 M1 IV T4 N3 M1 IV T4 NX M1 IV T4 N0 MX UNK T4 N1 MX UNK T4 N2 MX UNK T4 N3 MX UNK T4 NX MX UNK TX N0 M0 UNK TX N1 M0 UNK TX N2 M0 IIIB TX N3 M0 IIIB TX NX M0 UNK TX N0 M1 IV TX N1 M1 IV TX N2 M1 IV TX N3 M1 IV TX NX M1 IV TX N0 MX UNK TX N1 MX UNK TX N2 MX UNK TX N3 MX UNK TX NX MX UNK &commonsummarystage; Extension Size Table Note: For CS Extension codes 100-400 ONLY, the T category is assigned based on the value of CS Tumor Size as shown in this table. CS Extension CS Tumor Size 000 0 CS Tumor Size 001-020 1 20 CS Tumor Size 021-050 21 50 CS Tumor Size 051-989 51 989 CS Tumor Size 990-991 990 991 CS Tumor Size 992 992 CS Tumor Size 993-994 993 994 CS Tumor Size 995 995 CS Tumor Size 996 996 CS Tumor Size 997-998 997 998 CS Tumor Size 999 999 100 ERROR T1 T2 T3 T1 T1 T2 T2 T3 ERROR TX 110 ERROR T1 T2 T3 T1 T1 T2 T2 T3 ERROR TX 120 ERROR T1 T2 T3 T1 T1 T2 T2 T3 ERROR TX 160 ERROR T1 T2 T3 T1 T1 T2 T2 T3 ERROR TX 200 ERROR T1 T2 T3 T1 T1 T2 T2 T3 ERROR TX 300 ERROR T1 T2 T3 T1 T1 T2 T2 T3 ERROR TX 310 ERROR T1 T2 T3 T1 T1 T2 T1 T1 ERROR T1 320 ERROR T1 T2 T3 T1 T2 T2 T2 T2 ERROR T2 330 ERROR T1 T2 T3 T1 T3 T2 T3 T3 ERROR T3 400 ERROR T1 T2 T3 T1 T1 T2 T2 T3 ERROR TX