]> C69.0 Conjunctiva Note: Laterality must be coded for this site. OBSOLETE CS Tumor Size Note: CS Tumor Size is obsolete beginning with CS Version 2 (codes and notes). Old data are retained, but new cases are not coded with CS Tumor Size. Use code 988 for this field. Code Description 000 001-979 980 981-987 988 989 990 991 992 993 994 995 999 CS Extension Note 1: Palpebral and tarsal conjunctiva line the eyelid, bulbar conjunctiva covers the eyeball, forniceal conjunctiva covers the space between the eyelid and the globe. According to the AJCC, tumors are most likely to arise at the exposed site where the conjunctival epithelium merges with the corneal epithelium, particularly at the temporal limbus. Note 2: Use code 140 or 150 if the physician's assignment of T category is the only information available about the extent of the tumor. Note 3: The CS Tumor Size table for this schema is obsolete in CS Version 2, and the collection of tumor size value moved to CS Site-Specific Factor 1, Tumor Size. Code Description TNM 7 Map TNM 6 Map SS77 Map SS2000 Map 000 In situ, intraepithelial, noninvasive Tis Tis IS IS 100 ERROR ** L L 110 ^ * L L 120 ^ * L L 140 Stated as T1 with no other information on extension ^ * L L 150 Stated as T2 with no other information on extension ^ * L L 300 ERROR ** L L 350 Localized, NOS ^ * L L 400 T3 T3 L L 500 ERROR T3 RE RE 510 T3 T3 RE RE 530 T3 T3 RE RE 550 Stated as T3 with no other information on extension T3 T3 RE RE 700 ERROR ERROR ERROR ERROR 710 T4a T4a RE RE 720 T4b T4b RE RE 730 Orbit, NOS T4NOS T4NOS RE RE 780 T4c T4c RE RE 790 T4d T4d D D 800 Further contiguous extension T4d T4d D D 810 Stated as T4 [NOS] with no other information on extension T4NOS T4NOS RE RE 950 No evidence of primary tumor T0 T0 U U 999 TX TX U U ^ For CS Extension codes 110-150, and 350 ONLY, the T category for AJCC 7 staging is assigned based on the value of CS Site-Specific Factor 1, Tumor Size, as shown in the Extension Size Table CSv2. * For CS Extension codes 110-150, and 350 ONLY, the T category for AJCC 6 staging collected in CSv2 is assigned based on the value of CS Site-Specific Factor 1, Tumor Size, as shown in the Extension Size Table CSv2. ** For CS Extension codes 100 and 300 ONLY, the T category for AJCC 6 staging collected in CSv1 is assigned based on the value of CS Tumor Size as shown in the Extension Size Table CSv1. &generalcstsexteval; &commonlymphnodeseye; &generalregnodeseval; &generalreglnpos; &generalreglnexam; &generalmetsatdx; &generalmetseval; CS Site-Specific Factor 1 Tumor Size Note 1: Code the largest dimension of the tumor. Record the actual measurement in tenths of millimeters. Refer to the General Instructions in Part I for coding CS Tumor Size, when coding tumor size in this field. Note 2: Code the specific tumor size as stated in the medical record. Use code 991 or 992 if the physician's statement about T value is the only information available about the size of the tumor. Code Description 000 No mass/tumor found 001-979 980 98.0 mm or larger 988 990 991 992 999 CS Site-Specific Factor 2 Ki-67/MIB Labeling Index (LI): Ophthalmic Note 1: Ki-67 antigen is a nuclear protein, expressed by cells in all phases of the active cell cycle (G1, S, G2, and M phase) and absent in resting cells (G0 phase). Tumor cells with positive staining for Ki-67 antibodies are actively growing or proliferating. The fraction of Ki-67-positive tumor cells (the Ki-67 labeling index, or LI) may correlate with the clinical course of cancer. The value is expressed as the percentage of carcinoma cells in the tissue sample with positive immunohistochemical staining for the Ki-67 protein. The staining may be performed with the MIB-1 monoclonal antibody, so the test may be referred to as either Ki-67 or MIB-1. Note 2: Code the LI fraction percentage using Ki-67 or MIB-1 (monoclonal antibody) when it is available on the pathology report of the primary tumor. The Ki-67 or MIB-1 LI may also be called the growth fraction or proliferative fraction. Note 3: Record the LI as an exact whole number (000-100). For example, if the LI level is recorded by the pathologist as 15%, assign code 015. If the percentage is documented as 13.7%, round up to 14% and assign code 014. If the percentage is documented as 13.2%, round down to 13% and assign code 013. If the percentage is documented as less than 0.5%, round down to 0% and code 000; if the percentage is documented as greater than 0.5% and less than 1%, round up to 1% and code as 001. Note 4: In the absence of a specific percentage value, use codes 110-140 for a stated range of the LI, or codes 991-993 for an interpretation of the LI. Code Description 000-100 110 Stated as Ki-67 growth fraction less than or equal to 5% 120 Stated as Ki-67 growth fraction greater than 5% and less than or equal to 10% 130 Stated as Ki-67 growth fraction greater than 10% and less than or equal to 20% 140 Stated as Ki-67 growth fraction greater than 20% and less than or equal to 50% 150 Stated as Ki-67 growth fraction greater than 50% 888 988 991 Stated as low proliferation rate 992 Stated as increased proliferation rate 993 Stated as high proliferation rate 997 Ki-67 growth fraction study performed, results not available 998 Test not done (test not ordered and not performed) 999 ¬appssfactor3; ¬appssfactor4; ¬appssfactor5; ¬appssfactor6; ¬appnewssf7; ¬appnewssf8; ¬appnewssf9; ¬appnewssf10; ¬appnewssf11; ¬appnewssf12; ¬appnewssf13; ¬appnewssf14; ¬appnewssf15; ¬appnewssf16; ¬appnewssf17; ¬appnewssf18; ¬appnewssf19; ¬appnewssf20; ¬appnewssf21; ¬appnewssf22; ¬appnewssf23; ¬appnewssf24; ¬appnewssf25; &commonhistinclusioncarcinoma; &commonhistologyexclusions1; ¬appscsstageanytnm7; ¬appscsstageanytnm; &commonsummarystage; Extension Size Table CSv2 Note: For CS Extension codes 110- 150 and 350 ONLY, the T category for AJCC staging is assigned based on the value of CS Extension and CS Site-Specific Factor 1, Tumor Size, as shown in this table. The CS Tumor Size table for this schema is obsolete in CS Version 2, and the collection of tumor size value moved to CS Site-Specific Factor 1, Tumor Size. CS Extension CS SSF 1 Tumor Size 000 0 CS SSF 1 Tumor Size 001-050 1 50 CS SSF 1 Tumor Size 051-980 51 980 CS SSF 1 Tumor Size 988 988 CS SSF 1 Tumor Size 990-991 990 991 CS SSF 1 Tumor Size 992 992 CS SSF 1 Tumor Size 999 999 110 ERROR T1 T2 ERROR T1 T2 TX 120 ERROR T1 T2 ERROR T1 T2 TX 140 ERROR T1 T2 ERROR T1 T2 T1 150 ERROR T1 T2 ERROR T1 T2 T2 350 ERROR T1 T2 ERROR T1 T2 TX Extension Size Table CSv1 Note: For the obsolete CS Extension codes 100 and 300 ONLY, the T category for AJCC 6 staging for cases collected in CSv1 and not updated to CSv2 codes is assigned based on the value of CS Extension and the obsolete CS Tumor Size code as shown in this table. CS Extension CS Tumor Size 000 0 CS Tumor Size 001-005 1 5 CS Tumor Size 006-980 6 980 CS Tumor Size 981-989 981 989 CS Tumor Size 990 990 CS Tumor Size 991-995 991 995 CS Tumor Size 999 999 100 ERROR T1 T2 ERROR T1 T2 TX 300 ERROR T1 T2 ERROR T1 T2 TX