]> C22.0 Liver C22.1 Intrahepatic bile duct Note 1: For C22.0, the Liver schema includes only M-8000-8157,8162-8175,8190-9136,9141-9582, and 9700-9701. For cholangiocarcinoma (M-8160,8161, and 8180), see BileDuctsIntraHepat schema. Note 2: For C22.1, the Liver schema includes only M-8170-8175. For other histologies, see BileDuctsIntraHepat schema. Note 3: AJCC 7 TNM staging will be derived for hepatocellular carcinoma only, M-8170-8175 for liver (C22.0). &commonsizebiliary; CS Extension Note 1: In codes 390, 400, and 440, "multiple (satellite) nodules/tumors" includes satellitosis, multifocal tumors, and intrahepatic metastases. Note 2: Major vascular invasion (code 630) is defined as invasion of the branches of the main portal vein (right or left portal vein, not including sectoral or segmental branches) or as invasion of one or more of the three hepatic veins (right, middle, or left). Invasion of hepatic artery or vena cava is coded to 660. Code Description TNM 7 Map TNM 6 Map SS77 Map SS2000 Map 100 T1 T1 L L 150 T1 T1 RE RE 170 T1 T1 L L 200 ERROR ERROR ERROR ERROR 250 T1 T1 RE RE 270 T1 T1 L L 300 ERROR ERROR ERROR ERROR 350 T2 T2 L L 370 T2 T2 RE RE 380 T2 T2 RE RE 390 ^ * L L 400 ^ * L L 420 ^ * RE RE 440 ^ * D RE 460 T2 T2 L L 500 ERROR ERROR ERROR ERROR 510 ERROR ERROR ERROR ERROR 520 ERROR ERROR ERROR ERROR 530 ERROR ERROR ERROR ERROR 540 ERROR ERROR ERROR ERROR 550 ERROR ERROR ERROR ERROR 560 ERROR ERROR ERROR ERROR 580 ERROR ERROR ERROR ERROR 600 Stated as T3a with no other information regarding extension T3a T3 RE RE 630 T3b T3 RE RE 635 T3b T3 D RE 638 T3b T3 RE RE 639 Stated as T3 [NOS] with no other information on extension T3NOS T3 RE RE 640 Direct extension/perforation of visceral peritoneum T4 T4 RE RE 645 Extrahepatic bile ducts T4 T4 RE RE 650 ERROR ERROR ERROR ERROR 660 Extension to hepatic artery or vena cava T4 T4 RE RE 670 ERROR ERROR ERROR ERROR 700 Diaphragm T4 T4 RE RE 750 T4 T4 RE RE 755 T4 T4 RE RE 760 ERROR ERROR ERROR ERROR 770 T4 T4 D RE 800 T4 T4 D D 805 ERROR ERROR ERROR ERROR 810 Stated as T4 with no other information on extension T4 T4 D D 950 No evidence of primary tumor T0 T0 U U 999 TX TX U U ^ For CS Extension codes 390, 400, 420, and 440 ONLY, the T category for AJCC 7 staging is assigned based on the value of CS Tumor Size, as shown in the Extension Size AJCC 7 Table for this schema. * For CS Extension codes 390, 400, 420, and 440 ONLY, the T category for AJCC 6 staging is assigned based on the value of CS Tumor Size, as shown in the Extension Size AJCC 6 Table for this schema. &commoncstsextevalliver; CS Lymph Nodes Note 1: Code only regional nodes and nodes, NOS, in this field. Distant nodes are coded in CS Mets at DX. Note 2: Inferior phrenic nodes are classified as regional nodes for AJCC 7 staging. Code Description TNM 7 Map TNM 6 Map SS77 Map SS2000 Map 000 No regional lymph node involvement N0 N0 NONE NONE 100 N1 N1 RN RN 200 Inferior phrenic nodes N1 N0 D D 300 200 + 100 N1 N1 D D 350 Stated as N1 with no other information on regional lymph nodes N1 N1 RN RN 800 N1 N1 RN RN 805 N1 N1 RN RN 999 NX NX U U &generalregnodeseval; &generalreglnpos; &generalreglnexam; CS Mets at DX Note: Inferior phrenic nodes were reclassified from distant to regional nodes in AJCC 7th Edition. They are now coded in CS Lymph Nodes. Code Description TNM 7 Map TNM 6 Map SS77 Map SS2000 Map 00 No distant metastasis M0 * NONE NONE 10 Distant lymph node(s), NOS M1 M1 D D 11 M1 M1 RN D 12 M1 M1 RN D 13 M1 M1 D D 15 ERROR M1 D D 16 Distant lymph node(s) other than codes 10-13 M1 M1 D D 40 M1 M1 D D 50 ERROR M1 D D 51 M1 M1 D D 52 M1 M1 D D 60 M1 M1 D D 99 M0 * U U * For CS Mets at DX codes 00 and 99, the M category for AJCC 6 staging is assigned based on the coding of CS Lymph Nodes as shown in the Lymph Nodes Mets at DX AJCC 6 Table. &generalmetseval; &commonssf1liver; &commonssf2liver; &commonssf3liver; CS Site-Specific Factor 4 Creatinine Value Note 1: The Model for End-Stage Liver Disease (MELD) is a numerical scale used to determine how urgently a patient with liver disease needs a liver transplant within the next three months. Results from three routine lab tests are used to calculate the MELD score. Creatinine, one of the tests, measures kidney function; impaired kidney function is often associated with severe liver disease. Note 2: Normal values may vary from lab to lab. The typical human reference ranges are 0.5 to 1.0 milligrams/deciliter (mg/dl) (about 45-90 micromoles/liter (umol/l) for women and 0.7 to 1.2 mg/dl (60-110 umol/l) for men. Note 3: Record the blood or serum creatinine value for this data item Note 4: Record to the nearest tenth in mg/dl or umol/l the highest creatinine value prior to surgery. Record a creatinine value of 0.53 mg/dL as 005; record a value of 60 umol/l as 600; and record a value of 110 umol/l as 980. Note 5: Record the creatinine unit of measure for the same laboratory test in CS Site-Specific Factor 5. Note 6: Use code 997 ff the test was done but the actual value is not statedUse code 997 If the test was done but the unit is not in mg/dl or umol/l. Code Description 000 001 002-979 980 988 997 998 999 CS Site-Specific Factor 5 Creatinine Unit of Measure Note 1: There are two main methods of describing concentrations: by weight, and by molecular count. Weights are recorded in grams, and molecular counts are recorded in moles. Milligrams/deciliter (mg/dl) is the unit of measure commonly used in the United States, and micromoles/liter (umol/l) is the designated Systeme Internationale (SI) unit of measure commonly used in Canada and Europe. 1 mg/dl of creatinine is 88.4 umol/l. Note 2: The same laboratory test should be used to record information in CS Site-Specific Factors 4 and 5. Code Description 000 010 Milligrams/deciliter (mg/dl) 020 Micromoles/liter (umol/l) 888 988 997 998 999 CS Site-Specific Factor 6 Total Bilirubin Value Note 1: The Model for End-Stage Liver Disease (MELD) is a numerical scale used to determine how urgently a patient with liver disease needs a liver transplant within the next three months. Results from three routine lab tests are used to calculate the MELD score. Bilirubin, one of the tests, measures how effectively the liver excretes bile. Note 2: Assay of total bilirubin includes conjugated (direct) and unconjugated (indirect) bilirubin. Record the total bilirubin value for this data item. Note 3: Normal values may vary from lab to lab. The typical human reference ranges are 0.5 to 1.0 milligrams/deciliter (mg/dl) (about 45-90 micromoles/liter (umol/l) for women and 0.7 to 1.2 mg/dl (60-110 umol/l) for men. Note 4: Record to the nearest tenth of mg/dl or umol/l the highest total bilirubin value prior to surgery. Record a total bilirubin value of 0.53 mg/dl as 005; record a value of 5.3 umol/l as 053. Note 5: Record the total bilirubin unit of measure for the same laboratory test in CS Site-Specific Factor 6. Note 6: Use code 997 if the test was done but the actual value is not stated. Use code 997 if the test was done but the unit is not in mg/dl or umol/l. Code Description 000 001 002-979 980 988 997 998 999 CS Site-Specific Factor 7 Total Bilirubin Unit of Measure Note 1: There are two main methods of describing concentrations: by weight, and by molecular count. Weights are recorded in grams, and molecular counts are recorded in moles. Milligrams/deciliter (mg/dl) is the unit of measure commonly used in the United States. Micromoles/liter (umol/l) is the designated Systeme International (SI) unit of measure commonly used in Canada and Europe. Note 2: If the test was done but the total bilirubin unit of measure is not stated, code 997. Note 3: The same laboratory test should be used to record information in CS Site-Specific Factors 6 and 7. Code Description 000 010 Milligrams per deciliter (mg/dL) 020 Micromoles/liter (umol/L) 988 997 998 999 CS Site-Specific Factor 8 International Normalized Ratio for Prothrombin Time (INR) Note 1: The Model for End-Stage Liver Disease (MELD) is a numerical scale used to determine how urgently a patient with liver disease needs a liver transplant within the next three months. Results from three routine lab tests are used to calculate the MELD score. International normalized ratio for prothrombin time (INR), one of the tests, measures the liver's ability to make blood clotting factors. Note 2: The normal range for a healthy person is 0.9-1.3. A high INR level such as INR=5 indicates that there is a high chance of bleeding. A low level such as INR = 0.5 indicates a high chance of abnormal clotting. Normal values may vary from lab to lab. Note 3: Record INR of 0.5 as 005; record INR of 5 as 050. Note 4: If the test was done but the actual value is not stated, code 997. Code Description 000 001 0.1 or less 002-099 100 INR 10.0 or greater 988 997 998 999 ¬appnewssf9; ¬appnewssf10; ¬appnewssf11; ¬appnewssf12; ¬appnewssf13; ¬appnewssf14; ¬appnewssf15; ¬appnewssf16; ¬appnewssf17; ¬appnewssf18; ¬appnewssf19; ¬appnewssf20; ¬appnewssf21; ¬appnewssf22; ¬appnewssf23; ¬appnewssf24; ¬appnewssf25; &commonhistinclusionliver; &commonhistologyexclusions1; AJCC TNM 7 Stage T N M Stage T0 N0 M0 ERROR T0 N1 M0 IVA T0 NX M0 UNK T1 N0 M0 I T1 N1 M0 IVA T1 NX M0 UNK T2 N0 M0 II T2 N1 M0 IVA T2 NX M0 UNK T3a N0 M0 IIIA T3a N1 M0 IVA T3a NX M0 UNK T3b N0 M0 IIIB T3b N1 M0 IVA T3b NX M0 UNK T3NOS N0 M0 IIINOS T3NOS N1 M0 IVA T3NOS NX M0 UNK T4 N0 M0 IIIC T4 N1 M0 IVA T4 NX M0 UNK TX N0 M0 UNK TX N1 M0 IVA TX NX M0 UNK T0 N0 M1 IVB T0 N1 M1 IVB T0 NX M1 IVB T1 N0 M1 IVB T1 N1 M1 IVB T1 NX M1 IVB T2 N0 M1 IVB T2 N1 M1 IVB T2 NX M1 IVB T3a N0 M1 IVB T3a N1 M1 IVB T3a NX M1 IVB T3b N0 M1 IVB T3b N1 M1 IVB T3b NX M1 IVB T3NOS N0 M1 IVB T3NOS N1 M1 IVB T3NOS NX M1 IVB T4 N0 M1 IVB T4 N1 M1 IVB T4 NX M1 IVB TX N0 M1 IVB TX N1 M1 IVB TX NX M1 IVB AJCC TNM 6 Stage T N M Stage T0 N0 M0 ERROR T0 N1 M0 IIIC T0 NX M0 UNK T0 N0 M1 IV T0 N1 M1 IV T0 NX M1 IV T0 N0 MX UNK T0 N1 MX UNK T0 NX MX UNK T1 N0 M0 I T1 N1 M0 IIIC T1 NX M0 UNK T1 N0 M1 IV T1 N1 M1 IV T1 NX M1 IV T1 N0 MX UNK T1 N1 MX UNK T1 NX MX UNK T2 N0 M0 II T2 N1 M0 IIIC T2 NX M0 UNK T2 N0 M1 IV T2 N1 M1 IV T2 NX M1 IV T2 N0 MX UNK T2 N1 MX UNK T2 NX MX UNK T3 N0 M0 IIIA T3 N1 M0 IIIC T3 NX M0 IIINOS T3 N0 M1 IV T3 N1 M1 IV T3 NX M1 IV T3 N0 MX UNK T3 N1 MX UNK T3 NX MX UNK T4 N0 M0 IIIB T4 N1 M0 IIIC T4 NX M0 IIINOS T4 N0 M1 IV T4 N1 M1 IV T4 NX M1 IV T4 N0 MX UNK T4 N1 MX UNK T4 NX MX UNK TX N0 M0 UNK TX N1 M0 IIIC TX NX M0 UNK TX N0 M1 IV TX N1 M1 IV TX NX M1 IV TX N0 MX UNK TX N1 MX UNK TX NX MX UNK &commonsummarystage; Extension Size AJCC 7 Table Note: For CS Extension codes 390, 400, 420, and 440 ONLY, the T category is assigned based on the value of CS Tumor Size, as shown in this table. CS Extension CS Tumor Size 000 0 CS Tumor Size 001-050 1 50 CS Tumor Size 051-989 51 989 CS Tumor Size 990-995 990 995 CS Tumor Size 996 996 CS Tumor Size 997-998 997 998 CS Tumor Size 999 999 390 ERROR T2 T3a T2 T3a ERROR TX 400 ERROR T2 T3a T2 T3a ERROR TX 420 ERROR T2 T3a T2 T3a ERROR TX 440 ERROR T2 T3a T2 T3a ERROR TX Extension Size AJCC 6 Table Note: For CS Extension codes 390, 400, 420, and 440 ONLY, the T category is assigned based on the value of CS Tumor Size, as shown in this table. CS Extension CS Tumor Size 000 0 CS Tumor Size 001-050 1 50 CS Tumor Size 051-989 51 989 CS Tumor Size 990-995 990 995 CS Tumor Size 996 996 CS Tumor Size 997-998 997 998 CS Tumor Size 999 999 390 ERROR T2 T3 T2 T3 ERROR TX 400 ERROR T2 T3 T2 T3 ERROR TX 420 ERROR T2 T3 T2 T3 ERROR TX 440 ERROR T2 T3 T2 T3 ERROR TX Lymph Nodes Mets at DX AJCC 6 Table Note: For CS Mets at DX codes 00 and 99, the M category for AJCC 6 staging is assigned as shown in this table. CS Lymph Nodes CS Mets at DX 00 0 CS Mets at DX 99 99 000-100 M0 MX 200-300 M1 M1 350-999 M0 MX